Using Stem Cells in Sutures to promote wound healing

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Article Info
Brevy ID AID2016061212250901
Author(s) Ann Katharin Reckhenrich, Bianca Manuela Kirsch, Elizabeth Ann Wahl, Thilo Ludwig Schenck, Farid Rezaeian, Yves Harder, Peter Foehr, Hans-Günther Machens, José Tomás Egaña
Publication Date 2014
Published in PLoS ONE
Domain

Biology

Subdomain Wound healing
DOI 10.1371/journal.pone.0091169
ISSN 1932-6203
Citations

APA

Ann Katharin Reckhenrich, Bianca Manuela Kirsch, Elizabeth Ann Wahl, Thilo Ludwig Schenck, Farid Rezaeian, Yves Harder, Peter Foehr, Hans-Günther Machens, José Tomás Egaña (2014) Using Stem Cells in Sutures to promote wound healing. PLoS ONE, 9(3), e91169.

Chicago

Ann Katharin Reckhenrich, Bianca Manuela Kirsch, Elizabeth Ann Wahl, Thilo Ludwig Schenck, Farid Rezaeian, Yves Harder, Peter Foehr, Hans-Günther Machens, José Tomás Egaña "Using Stem Cells in Sutures to promote wound healing." PLoS ONE 9, no. 3 (2014): e91169.

MLA

Ann Katharin Reckhenrich, Bianca Manuela Kirsch, Elizabeth Ann Wahl, Thilo Ludwig Schenck, Farid Rezaeian, Yves Harder, Peter Foehr, Hans-Günther Machens, José Tomás Egaña "Using Stem Cells in Sutures to promote wound healing." PLoS ONE 9.3 (2014): e91169.

Topic Tags Stem cells, sutures
Download Link(s) Unknown

Last edited by Mcli3dw2 during 06/2016.

Quick Summary

Sutures are commonly used to aid wound healing and incorporating stem cells within them releases growth factors to aid this further.

Overall Results & Conclusion

Researchers have been able to culture Mesenchymal Stem Cells derived from Adipose tissue within standard biodegradable sutures. The cells remained viable for up to ten days in cell culture and released VEGF, necessary for wound healing, as well as a range of cytokines into the cell media during this time. The cells did impact on the mechanical properties of the sutures but wouldn't impact on their use in humans provided they weren't stretched too far.

Further Information

Expand this section to access further information such as the work's methods, significance, and any critical response.

Methodology

In this paper the researchers used standard biodegradable sutures (Vicryl from Johnson and Johnson) and Mesenchymal stem cells were injected in the centre. As a control sutures without stem cells were also subject to the same conditions. Cell viability was determined via an MTT assay, growth factors through an ELISA assay and cytokines through a protein array. This demonstrated the cells were alive, increasing in number and producing factors that are known to stimulate wound healing. Mechanical tests were completed using a tensile test using a uniaxial system.

Significance

Wound healing can be problematic for a number of patients, eg diabetics, and open wounds increases the likelihood of infections that can cause further tissue damage. In order to restore as much tissue functionality as possible researchers are building on existing techniques, such as sutures, to see what they can do to improve and speed up this process.

Article Info
Brevy ID AID2016061212250901
Author(s) Ann Katharin Reckhenrich, Bianca Manuela Kirsch, Elizabeth Ann Wahl, Thilo Ludwig Schenck, Farid Rezaeian, Yves Harder, Peter Foehr, Hans-Günther Machens, José Tomás Egaña
Publication Date 2014
Published in PLoS ONE
Domain

Biology

Subdomain Wound healing
DOI 10.1371/journal.pone.0091169
ISSN 1932-6203
Citations

APA

Ann Katharin Reckhenrich, Bianca Manuela Kirsch, Elizabeth Ann Wahl, Thilo Ludwig Schenck, Farid Rezaeian, Yves Harder, Peter Foehr, Hans-Günther Machens, José Tomás Egaña (2014) Using Stem Cells in Sutures to promote wound healing. PLoS ONE, 9(3), e91169.

Chicago

Ann Katharin Reckhenrich, Bianca Manuela Kirsch, Elizabeth Ann Wahl, Thilo Ludwig Schenck, Farid Rezaeian, Yves Harder, Peter Foehr, Hans-Günther Machens, José Tomás Egaña "Using Stem Cells in Sutures to promote wound healing." PLoS ONE 9, no. 3 (2014): e91169.

MLA

Ann Katharin Reckhenrich, Bianca Manuela Kirsch, Elizabeth Ann Wahl, Thilo Ludwig Schenck, Farid Rezaeian, Yves Harder, Peter Foehr, Hans-Günther Machens, José Tomás Egaña "Using Stem Cells in Sutures to promote wound healing." PLoS ONE 9.3 (2014): e91169.

Topic Tags Stem cells, sutures
Download Link(s) Unknown

Last edited by Mcli3dw2 during 06/2016.

Quick Summary

This section data hasn't yet been added. Please edit this page to provide the information.

Overall Results & Conclusion

This section data hasn't yet been added. Please edit this page to provide the information.

Further Information

Expand this section to access further information such as the work's methods, significance, and any critical response.

Methodology

This section data hasn't yet been added. Please edit this page to provide the information.

Significance

This section data hasn't yet been added. Please edit this page to provide the information.